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Folic acid fortification is a process where synthetic folic acid is added to wheat flour or other foods with the intention of promoting public health through increasing blood folate levels in the populace. It is used as it is more stable during processing and storage.
Signs of folate deficiency anemia most of the time are subtle. [4] Anemia (macrocytic, megaloblastic anemia) can be a sign of advanced folate deficiency in adults. [1] Folate deficiency anemia may result in feeling tired, weakness, changes to the color of the skin or hair, open sores on the mouth, shortness of breath, palpitations, lightheadedness, cold hands and feet, headaches, easy bleeding ...
Government-mandated fortification of foods with folic acid has reduced the incidence of NTDs by 25% to 50% in more than 60 countries using such fortification. [10] Deficiency can also result from rare genetic factors, such as mutations in the MTHFR gene that lead to compromised folate metabolism.
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A second hypothesis involves the methylation of genes in vascular cells by folic acid and vitamin B 12, which may also accelerate plaque growth. Finally, altered methylation may catalyse l-arginine to asymmetric dimethylarginine, which is known to increase the risk of vascular disease.
The large-scale study, which looked at the data of 867,000 American adults over two years, showed a beneficial association between taking prescription folic acid — a B vitamin that helps the ...
Folic acid, which is the synthetic form of the vitamin folate, is critical both in pre- and peri-conception. [7] Deficiencies in folic acid may cause neural tube defects (NTDs). Women who had 0.4 mg of folic acid in their systems due to supplementing 3 months before childbirth significantly reduced the risk of NTDs. [29]