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In 1998, Thomson's Lab was the first to report the successful isolation of human embryonic stem cells. On November 6, 1998, Science published this research in an article titled "Embryonic Stem Cell Lines Derived from Human Blastocysts", results which Science later featured in its “Scientific Breakthrough of the Year” article, 1999. [3]
Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.
Working together, biologists James Till and Ernest McCulloch made significant contributions to stem cell research.While studying the effects of radiation on the bone marrow of mice at the Ontario Cancer Institute in Toronto, they demonstrated the existence of multipotent stem cells in 1961, helping lay the foundation for modern stem cell biology and regenerative medicine.
He is the recipient of national and international awards in recognition of his medical research, [11] including appointment as an Officer of the Order of Australia. [12] His 2021 book, Flesh Made New: The Unnatural History and Broken Promise of Stem Cells, co-authored by Carl Power, was longlisted for that year's Walkley Book Award. [13]
For over 90 years, hematopoietic stem cell transplantation (HSCT) has been used to treat people with conditions such as leukaemia and lymphoma; this is the only widely practiced form of stem-cell therapy. [94] [97] [98] As of 2016, the only established therapy using stem cells is hematopoietic stem cell transplantation. [99]
A woman has undergone a stem-cell therapy made from her own cells, to treat her type 1 diabetes. Researchers in China discovered the woman did not need to use insulin 75 days after the procedure ...
Wnt-1 was later discovered to be a key player in the stem cell self-renewal pathway. [8] She joined the biotech company SyStemix from 1989 to 1997, [9] where she co-discovered the human hematopoietic stem cell (hHSC) and played a leading role in the launch of the clinical research program for this cell. The purified hHSC was shown to be cancer ...
In 1997, Dick reported the detection of cancer stem cells at the root of three other forms of leukemia. This time he presented it as the "cancer stem-cell hypothesis". His model stated that there are different cancer cells and amongst them there is a pecking order in which the abnormal stem cell, is both the key to forming and feeding a cancer ...
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