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Liver regeneration is the process by which the liver is able to replace damaged or lost liver tissue. The liver is the only visceral organ with the capacity to regenerate. [ 1 ] [ 2 ] The liver can regenerate after partial hepatectomy or injury due to hepatotoxic agents such as certain medications, toxins, or chemicals. [ 3 ]
The human liver is particularly known for its ability to regenerate, and is capable of doing so from only one quarter of its tissue, [35] due chiefly to the unipotency of hepatocytes. [36] Resection of liver can induce the proliferation of the remaining hepatocytes until the lost mass is restored, where the intensity of the liver's response is ...
The activated stellate cell as a myofibroblast is also responsible for secreting components of the extracellular matrix including collagen that can promote the development of fibrosis and the formation of scar tissue. Continued fibrosis is thought to be responsible for the development of cirrhosis and liver cancer. [10] [11]
The liver is the only human internal organ capable of natural regeneration of lost tissue; as little as 25% of a liver can regenerate into a whole liver. [75] This is, however, not true regeneration but rather compensatory growth in mammals. [ 76 ]
For these purposes, hepatocytes are usually isolated from animal or human [8] whole liver or liver tissue by collagenase digestion, which is a two-step process. In the first step, the liver is placed in an isotonic solution, in which calcium is removed to disrupt cell-cell tight junctions by the use of a calcium chelating agent .
Eventually, the remaining kidney can grow until its mass approaches the combined mass of two kidneys. [1] Along with the kidneys, compensatory growth has also been characterized in a number of other tissues and organs including: The adrenal glands [4] [5] The heart [5] [6] Muscles [5] The liver [5] [7] The lungs [8] The pancreas (beta cells and ...
Leifer died of cancer in June, aged 56. She was a programming executive who oversaw Grey’s Anatomy while working at ABC – the US network on which the show airs – as well as ABC Signature ...
[2] [3] [4] Regeneration can either be complete [5] where the new tissue is the same as the lost tissue, [5] or incomplete [6] after which the necrotic tissue becomes fibrotic. [ 6 ] At its most elementary level, regeneration is mediated by the molecular processes of gene regulation and involves the cellular processes of cell proliferation ...