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DHEA is also called dehydroisoandrosterone or dehydroandrosterone. Androstenedione (A4) is an androgenic steroid produced by the testes, adrenal cortex, and ovaries. While androstenedione is converted metabolically to testosterone and other androgens, it is also the parent structure of estrone.
The human brain. Differences in male and female brain size are relative to body size. [83] Early research into the differences between male and female brains showed that male brains are, on average, larger than female brains. This research was frequently cited to support the assertion that women are less intelligent than men.
For instance, in birds, male and female somatic cells may exhibit intrinsic differences due to CASI, but the extent to which these differences manifest in tissues can be influenced by circulating hormones such as estrogen and testosterone. Hormones act as amplifiers, enhancing or suppressing sex-specific characteristics that are intrinsically ...
The AR plays a role in regulating female sexual, somatic, and behavioral functions. Experimental data using AR knockout female mice, provides evidence that the promotion of cardiac growth, kidney hypertrophy, cortical bone growth and regulation of trabecular bone structure is a result of DNA-binding-dependent actions of the AR in females.
This protein has a low affinity for androgens. Therefore, testosterone can reach the brain without being taken up by alpha-fetoprotein. Due to fact that males have different levels of androgens in the brain, this can lead to organizing effects from androgen exposure with the expression of masculine behaviour.
The Sertoli cells are the point of origin for anti-Müllerian hormone. Once synthesized, the anti-Müllerian hormone initiates the ipsilateral regression of the Müllerian tract and inhibits the development of female internal features. At 10 weeks of gestation, the Leydig cells begin to produce androgen hormones.
In female: stimulates maturation of Graafian follicles in ovary. In male: spermatogenesis, enhances production of androgen-binding protein by the Sertoli cells of the testes. 27 Galanin: GAL Peptide: central nervous system and gastrointestinal tract: GALR1, GALR2, and GALR3: modulation and inhibition of action potentials in neurons: 28
In a female, on the other hand, absence of these levels of androgens results in development of typically female genitals. [4] Following this, sexual differentiation of the brain occurs; sex hormones exert organizational effects on the brain that will be activated in puberty. [ 4 ]