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Azadirachta indica, commonly known as neem, margosa, nimtree or Indian lilac, [3] is a tree in the mahogany family Meliaceae. It is one of the two species in the genus Azadirachta . It is native to the Indian subcontinent and to parts of Southeast Asia , but is naturalized and grown around the world in tropical and subtropical areas.
The genus Azadirachta was established by Adrien-Henri de Jussieu in 1830. [1] In 1753, Carl Linnaeus had described two species, Melia azedarach and Melia azadirachta. [3] De Jussieu considered Melia azadirachta to be sufficiently different from Melia azedarach to be placed in a new genus, Azadirachta, as Azadirachta indica. [4]
Although toxic, was used historically in Italy by women to enlarge their pupils, as well as a sedative, among other uses. The name itself means "beautiful woman" in Italian. [27]. Azadirachta indica: Neem: Used in India to treat worms, malaria, rheumatism and skin infections among many other things. Its many uses have led to neem being called ...
The ingestion of neem oil is potentially toxic and can cause metabolic acidosis, seizures, kidney failure, encephalopathy and severe brain ischemia in infants and young children. [2] [8] [9] Neem oil should not be consumed alone without any other solutions, particularly by pregnant women, women trying to conceive or children. [2]
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This molecule can also be found in neem oil at 0.12%. [3] Among the metabolites present in neem, nimbin is the least present chemical compound. [15] Nimbin biosynthesis is not influenced by environmental conditions [17] (temperature, rainfall, humidity…) because neem trees from the same agro-climatic zone can have very different nimbin ...
Azadirachtin is formed via an elaborate biosynthetic pathway, but is believed that the steroid tirucallol is the precursor to the neem triterpenoid secondary metabolites. Tirucallol is formed from two units of farnesyl diphosphate (FPP) to form a C 30 triterpene, but then loses three methyl groups to become a C 27 steroid.