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Charles River was founded in 1947 by Henry Foster, a young veterinarian who purchased one thousand rat cages from a Virginia farm and set up a one-person laboratory in Boston overlooking the Charles River. To fulfill the regional need for laboratory animal models, he bred, fed, and cared for the animals and personally delivered them to local ...
In laboratory animal husbandry, there is a huge demand for animals that have been kept in disease free conditions and housed in barrier units such as individually ventilated cages. This is very important because when animals are used for scientific research, particularly drug-related research, the animals must provide accurate and valid results.
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All laboratories using vertebrate lab animals in the United States are required by law to have a licensed veterinarian on staff and to adhere to the NIH Guide for the Use and Care of Laboratory Animals, which further stipulates that all protocols, including the sources for obtaining the animals, must be reviewed by an independent committee.
Harlan Sprague Dawley Inc. was a supplier of animals and other services to laboratories for the purpose of animal testing. [1] It provided pre-clinical research tools and services for the pharmaceutical, biotechnology, agrochemicals, industrial chemical, and food industries.
In 1996, AAALAC changed its name to the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International). The organization said the name change reflected the organization's growth in other countries and its commitment to enhancing life sciences and quality animal care around the world.
Institutional Animal Care and Use Committees (IACUCs) are centrally important in applying laws about animal research in the United States.Similar systems operate in other countries, but generally under different titles; for example, in Canada a typical title would be the University Animal Care Committee (UACC), while in the United Kingdom it would be the Animal Welfare and Ethical Review Body ...
Many laboratory animals, including mice and rats, are chronically stressed which can also negatively affect research outcomes and the ability to accurately extrapolate findings to humans. [ 33 ] [ 34 ] Researchers have also noted that many studies involving mice, rats and other rodents are poorly designed, leading to questionable findings.