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  2. Losartan/hydrochlorothiazide - Wikipedia

    en.wikipedia.org/wiki/Losartan/hydrochlorothiazide

    Losartan/hydrochlorothiazide, sold under the brand name Hyzaar among others, is a fixed-dose combination medication used to treat high blood pressure when losartan is not sufficient. [1] [2] It consists of losartan, an angiotensin II receptor blocker; and hydrochlorothiazide, a thiazide diuretic. [1] [2] It is taken by mouth. [1] [2]

  3. Losartan - Wikipedia

    en.wikipedia.org/wiki/Losartan

    Losartan, sold under the brand name Cozaar among others, is a medication used to treat high blood pressure (hypertension). [4] It is in the angiotensin receptor blocker (ARB) family of medication, and is considered protective of the kidneys.

  4. Angiotensin II receptor blocker - Wikipedia

    en.wikipedia.org/wiki/Angiotensin_II_receptor...

    Losartan, the first ARB. Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT 1) antagonists, [1] also known as angiotensin receptor blockers, [2] [3] angiotensin II receptor antagonists, or AT 1 receptor antagonists, are a group of pharmaceuticals that bind to and inhibit the angiotensin II receptor type 1 (AT 1) and thereby block the arteriolar contraction and ...

  5. Antihypertensive - Wikipedia

    en.wikipedia.org/wiki/Antihypertensive

    Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke, heart failure, kidney failure and myocardial infarction. Evidence suggests that a reduction of blood pressure by 5 mmHg can decrease the risk of stroke by 34% and of ischaemic heart disease by 21%.

  6. Management of hypertension - Wikipedia

    en.wikipedia.org/wiki/Management_of_hypertension

    Hypertension is usually treated to achieve a blood pressure of below 140/90 mmHg to 160/100 mmHg. According to one 2003 review, reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34% and of ischaemic heart disease by 21% and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. [1]

  7. Hydrochlorothiazide - Wikipedia

    en.wikipedia.org/wiki/Hydrochlorothiazide

    Hydrochlorothiazide is taken by mouth and may be combined with other blood pressure medications as a single pill to increase effectiveness. [4] Hydrochlorothiazide is a thiazide medication which inhibits reabsorption of sodium and chloride ions from the distal convoluted tubules of the kidneys, causing a natriuresis.

  8. ACE inhibitor and thiazide combination - Wikipedia

    en.wikipedia.org/wiki/ACE_inhibitor_and_thiazide...

    An ACE inhibitor and thiazide combination is a drug combination used to treat hypertension (high blood pressure). They are given by mouth.ACE inhibitors reduce the activity of angiotensin-converting enzyme (ACE) which produces angiotensin II, a hormone that constricts blood vessels.

  9. Discovery and development of angiotensin receptor blockers

    en.wikipedia.org/wiki/Discovery_and_development...

    A few clinical head-to-head comparisons have been made and candesartan, irbesartan and telmisartan appear to be slightly more effective than losartan in lowering blood pressure. [4] This difference may be related to different strengths of activity at the receptor level, such as duration and strength of receptor binding. [22]

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