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HDC aims to maximize the cytotoxic effects on cancer cells, but it also causes severe damage to the bone marrow, leading to a depletion of blood cell populations. The intensified chemotherapy targets the tumor cells more effectively, while the patient's normal bone marrow function is temporarily suppressed.
Nausea and vomiting are two of the most feared cancer treatment-related side-effects for people with cancer and their families. In 1983, Coates et al. found that people receiving chemotherapy ranked nausea and vomiting as the first and second most severe side-effects, respectively. [ 98 ]
It was promoted as a treatment for advanced breast cancer starting in the 1980s. [3] The treatment of high-dose chemotherapy with autologous bone marrow transplant had serious, lasting, and sometimes deadly side effects for the patient, including cardiac toxicity, sepsis, pulmonary failure, and nephrotoxicity, among others.
Patients receiving these agents experienced severe side-effects that limited the doses which could be administered, and hence limited the beneficial effects. Clinical investigators realized that the ability to manage these toxicities was crucial to the success of cancer chemotherapy. Several examples are noteworthy.
[12] [25] As with all chemotherapy, adverse effects are common, and many side effects have been documented. [17] [19] Because docetaxel is a cell-cycle-specific agent, it is cytotoxic to all dividing cells in the body. [26] This includes tumour cells as well as hair follicles, bone marrow and other germ cells.
Palliative chemotherapy is used to control (but not cure) the cancer in settings in which the cancer has spread beyond the breast and localized lymph nodes. See metastatic breast cancer. Combined therapies These combine, for example, non-drug treatments with localized chemotherapy to limit toxicity and achieve better results. [3]
Kate Middleton is opening up about the long-term side effects of her cancer treatment.. On Tuesday, Jan. 14, the Princess of Wales spoke with staff during a surprise visit to the Royal Marsden ...
Cyclophosphamide (CP), also known as cytophosphane among other names, [3] is a medication used as chemotherapy and to suppress the immune system. [4] As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. [4]