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The term "click chemistry" was coined in 1998 by Sharpless' wife, Jan Dueser, [3] who found the simplicity of this approach to chemical synthesis akin to clicking together Lego blocks. In fact, the simplicity of click chemistry represented a paradigm shift in synthetic chemistry, and has had significant impact in many industries, especially ...
The term "click chemistry" was coined by Sharpless around the year 2000, and was first fully described by Sharpless, Hartmuth Kolb, and M.G. Finn at The Scripps Research Institute in 2001. [ 11 ] [ 2 ] This involves a set of highly selective, exothermic reactions which occur under mild conditions; the most successful example is the azide alkyne ...
Americans Carolyn R. Bertozzi and K. Barry Sharpless, and Danish scientist Morten Meldal were cited for their work on click chemistry and bioorthogonal reactions, which are used to make cancer ...
American chemist Karl Barry Sharpless has referred to copper-catalyzed version of this cycloaddition as "the cream of the crop" of click chemistry [2] and "the premier example of a click reaction". [3] Thermal Huisgen 1,3-dipolar cycloaddition.
The prize was awarded equally to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for coming up with a way to snap molecules together. 2022 Nobel Prize In Chemistry Awarded To 3 ...
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He coined the term Click chemistry with Barry Sharpless and Hartmuth C. Kolb. He also works on the mechanism and optimisation of copper-catalysed azide-alkyl cycloaddition; on targeted synthesis of enzyme inhibitors and antivirals ; on bio-conjugation and chemical materials science; on the immunology of carbohydrates; and with new methods of ...
[1] [5] The associated scientific publication Click chemistry: diverse chemical function from a few good reactions has been cited more than 14,000 times (as of 2021) and was the foundation for the 2022 Nobel Prize in Chemistry for K. Barry Sharpless, Carolyn Bertozzi and Morten Meldal. [6]