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The old dose for pyrazinamide was 40–70 mg/kg daily and the incidence of drug-induced hepatitis has fallen significantly since the recommended dose has been reduced to 12–30 mg/kg daily. In the standard four-drug regimen (isoniazid, rifampicin, pyrazinamide, ethambutol ), pyrazinamide is the most common cause of drug-induced hepatitis. [ 13 ]
Patients at risk of peripheral neuropathy from other causes (diabetes mellitus, alcoholism, renal failure, malnutrition, pregnancy, etc.) should all be given pyridoxine 10 mg daily at the start of treatment. Please refer to the entry on isoniazid for details on other neurological side effects of INH. [citation needed]
It is a fixed dose combination of rifampicin, isoniazid, and pyrazinamide. [1] It is used either by itself or along with other antituberculosis medication. [1] It is taken by mouth. [1] Side effects are those of the underlying medications. [1] These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness ...
Some of the most popular drugs prescribed to treat bacterial infections can cause serious side effects and are overprescribed, according to studies and reports.
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Isoniazid decreases the metabolism of carbamazepine, thus slowing down its clearance from the body. People taking carbamazepine should have their carbamazepine levels monitored and, if necessary, have their dose adjusted accordingly. [38] It is possible that isoniazid may decrease the serum levels of ketoconazole after long-term treatment.
Clinical trials sponsored by Novo Nordisk found that participants with obesity or overweight (but without type 2 diabetes) lost 15.2 percent of their body weight after 104 weeks of 2.4 milligrams ...