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Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). [1] Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of the interferon genes. [2]
IRF3 is a member of the interferon regulatory transcription factor (IRF) family. [5] IRF3 was originally discovered as a homolog of IRF1 and IRF2.IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites. [6]
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The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. [5] It is a 13 kbp gene on chromosome 21q22.3 that encodes 545 amino acids. [ 6 ] AIRE is a transcription factor expressed in the medulla [ broken anchor ] (inner part) of the thymus .
In Texas, Florida, and more than a dozen other states, users who try to access the world’s largest pornography website are greeted by a surprising sight: a message on a black screen telling them ...
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Centrifugal governors, also known as "centrifugal regulators" and "fly-ball governors", were invented by Christiaan Huygens and used to regulate the distance and pressure between millstones in windmills in the 17th century.
The tattooed corpse of a woman was found bizarrely stuffed in a refrigerator dumped in some New Jersey woods — and cops say they need the public’s help identifying her.