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[9] [10] If rifamycin binds the polymerase after the chain extension process has started, no inhibition is observed on the biosynthesis, consistent with a steric-occlusion mechanism. Single step high level resistance to the rifamycins occurs as the result of a single amino acid change in the bacterial DNA dependent RNA polymerase.
Orally administered rifampicin results in peak plasma concentrations in about 2–4 hours. 4-Aminosalicylic acid (another antituberculosis drug) significantly reduces absorption of rifampicin, [56] and peak concentrations may be lower. If these two drugs must be used concurrently, they must be given separately, with an interval of 8 to 12 hours ...
It produces the rifamycin antibiotics (e.g., rifamycin SV), which are used to treat mycobacterial diseases such as tuberculosis and leprosy. [2] The type strain of Amycolatopsis rifamycinica (DSM 46095) has been reclassified several times. When it was first isolated from a French soil sample in 1957, it was identified as Streptomyces ...
For Mycobacterium tuberculosis, the rifamycin-resistant mutations most commonly encountered involve codons 516, 526, and 531 (numbered, by convention, as in Escherichia coli rpoB). [11] [12] These mutations result in high rifampicin resistance with a relatively low loss of fitness. [8]
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Rifapentine is in the rifamycin family of medication and works by blocking DNA-dependent RNA polymerase. [3] Rifapentine was approved for medical use in the United States in 1998. [2] It is on the World Health Organization's List of Essential Medicines. [4] In many areas of the world it is not easy to get as of 2015. [5]
"Omeprazole".Drug Information Portal.U.S. National Library of Medicine. "Amoxicillin".Drug Information Portal.U.S. National Library of Medicine. "Rifabutin".
Title English title Original airdate Production code 1 "Bolnica" The Hospital: December 22, 1974 (): 101: 2 "Garaža" The Garage: December 29, 1974 (): 102: 3 "Izdajnik" The Traitor