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Normally, HFE facilitates the binding of transferrin, which is iron's carrier protein in the blood. Transferrin levels are typically elevated at times of iron depletion (low ferritin stimulates the release of transferrin from the liver). When transferrin is high, HFE works to increase the intestinal release of iron into the blood.
The HFE gene provides instructions for producing a protein that is located on the surface of cells, primarily liver and intestinal cells. The HFE protein is also found on some immune system cells. The HFE protein interacts with other proteins on the cell surface to detect the amount of iron in the body.
Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
Human homeostatic iron regulator protein, also known as the HFE protein (High FE2+), is a transmembrane protein that in humans is encoded by the HFE gene. The HFE gene is located on short arm of chromosome 6 at location 6p22.2 [ 5 ]
Rheem Manufacturing Company is a privately held manufacturer who produces residential and commercial water heaters, boilers, heating, ventilating and air conditioning (HVAC) equipment. The company also produces and sells products under the Ruud brand name.
The deportation system moves faster for people held in custody. The cases of those held in detention are placed on the “detained docket” and those cases are heard more quickly. That is one ...
The advent of artificial intelligence (AI) is seen by many as one of the modern era's most incredible developments. And to be fair, it is a game changer.
In an appearance on "The Pacman Jones Show," the Hall of Famer and Colorado coach made it clear what he thinks the future holds for his son.
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