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Somatostatin is secreted by delta cells at several locations in the digestive system, namely the pyloric antrum, the duodenum and the pancreatic islets. [14]Somatostatin released in the pyloric antrum travels via the portal venous system to the heart, then enters the systemic circulation to reach the locations where it will exert its inhibitory effects.
Somatostatin is encoded by a CRE and is very susceptible to gene promoter region activation by transcription factor CREB. [1] There are five known somatostatin receptors: [2] SST 1 ; SST 2 ; SST 3 ; SST 4 ; SST 5 ; All are G protein-coupled seven transmembrane receptors.
The gene for somatostatin receptor 2, SSTR2 for short, is responsible for making a receptor for the signalling peptide, somatostatin (SST). Production occurs in the central nervous system, especially the hypothalamus, as well as the digestive system, and pancreas. [16] SSTR2 is a receptor for somatostatin-14 and -28 respectively.
20605 Ensembl ENSG00000139874 ENSMUSG00000035431 UniProt P30872 P30873 RefSeq (mRNA) NM_001049 NM_009216 RefSeq (protein) NP_001040 NP_033242 Location (UCSC) Chr 14: 38.21 – 38.21 Mb Chr 12: 58.26 – 58.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Somatostatin receptor type 1 is a protein that in humans is encoded by the SSTR1 gene. Function Somatostatin acts at many sites ...
The gene therapy will compete with Australia-based CSL Behring’s Hemgenix, a similar treatment that won FDA approval for hemophilia B in 2022. That drug has a similar list price of $3.5 million ...
Somatostatin receptor type 5 is a protein that in humans is encoded by the SSTR5 gene. [5] Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner.
The discovery of gene regulatory RNAs has led to attempts to develop drugs made of RNA, such as siRNA, to silence genes. [83] Adding to the Nobel prizes for research on RNA, in 2009 it was awarded for the elucidation of the atomic structure of the ribosome to Venki Ramakrishnan , Thomas A. Steitz , and Ada Yonath .
The agr (accessory gene regulator) locus [a] is one of the key sites of positive regulation for many of the S. aureus genes, including TSST-1. [9] Additionally, alterations in the expression of the genes ssrB and srrAB affect the transcription of TSST-1. [7] Further, high levels of glucose inhibit transcription, since glucose acts as a ...