Search results
Results from the WOW.Com Content Network
Cyclic peptides are polypeptide chains with a circular sequence of bonds, often found in nature or synthesized in the laboratory. They have various applications in medicine, such as antibiotics and immunosuppressive agents, and can be classified by the types of bonds that comprise the ring.
Peptides are short chains of amino acids linked by peptide bonds, and can be classified according to their sources and functions. Learn about ribosomal and nonribosomal peptides, peptide synthesis, peptide interactions, and peptide families with hormonal, antimicrobial, and other activities.
Learn how peptides are chemically synthesized by condensation of amino acids, and how solid phase peptide synthesis (SPPS) is used to assemble peptide chains. Find out about the coupling reagents, protecting groups, and purification techniques involved in peptide synthesis.
This page was last edited on 6 September 2021, at 23:16 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply.
The structural rigidity of cyclic RGD peptides improves their binding properties and prevents degradation at the highly susceptible aspartic acid residue, thereby increasing their stability. [30] Many RGD derivative drugs and diagnostics are cyclized, including Eptifibatide, Cilengitide, CEND-1, and 18 F-Galacto-RGD, and 18 F-Fluciclatide-RGD.
A number of natural antimicrobial peptides are cyclic, and the products of SICLOPPS are "increasingly viewed as ideal backbones for modulation of protein-protein interactions." [3] Circular peptides tend to be resistant to protease activity, and may be suitable for use as orally administered drugs.
Enterochelin is a depsipeptide that is an iron-transporter. [5]Several depsipeptides have been found to exhibit anti-cancer properties. [6]A depsipeptide enzyme inhibitor includes romidepsin, a member of the bicyclic peptide class, a known histone deacetylase inhibitors (HDACi).
Cyclotides are cyclic cystine knot peptides with diverse biological activities and structural features. They are isolated from various plant families and have a conserved gene structure and biosynthesis pathway.