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These medications work in combination to increase blood flow to the penis, resulting in an erection. [ 1 ] [ 2 ] [ 3 ] Alprostadil is a prostaglandin vasodilator that allows more blood to flow into the area by relaxing the smooth muscle in the blood vessels of the penis.
An intracavernous (or intracavernosal) injection is an injection into the base of the penis. This injection site is often used to administer medications to check for or treat erectile dysfunction in adult men (in, for example, a combined intracavernous injection and stimulation test ). [ 1 ]
Video_of_Penile_erection.ogv (Ogg multiplexed audio/video file, Theora/Vorbis, length 24 s, 320 × 240 pixels, 989 kbps overall, file size: 2.8 MB) This is a file from the Wikimedia Commons . Information from its description page there is shown below.
It consists of an intracavernosal injection, visual or manual sexual stimulation, and a rating of the subsequent erection. Neurogenic and hormonal influences are thus bypassed as the status of the blood vessels of the penis is assessed directly and objectively. A rigid erection of more than 10 minutes indicates normal function of veins.
When injected into the penis for erectile dysfunction; side effects may include penile pain, bleeding at the site of injection, and prolonged erection (priapism). [2] Prostaglandin E 1 is in the vasodilator family of medications. [2] It works by opening blood vessels and relaxing smooth muscle. [2]
Penile injections, on the other hand, can involve one of the following medications: papaverine, phentolamine, and prostaglandin E1, also known as alprostadil. [10] In addition to injections, there is an alprostadil suppository that can be inserted into the urethra. Once inserted, an erection can begin within 10 minutes and last up to an hour. [12]
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One dose intracavernosal injection contains 25 micrograms aviptadil and 2 mg of phentolamine mesilate for the treatment of ED. Aviptadil dose used for treatment of erectile dysfunction is a lot smaller than that for the treatment of ARDS. [10] [11]
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