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Unlike the other twelve vitamins, vitamin D is only conditionally essential - in a preindustrial society people had adequate exposure to sunlight and the vitamin was a hormone, as the primary natural source of vitamin D was the synthesis of cholecalciferol in the lower layers of the skin’s epidermis, triggered by a photochemical reaction with ...
It transports vitamin D metabolites between skin, liver and kidney, and then on to the various target tissues. [6] [9] As Gc protein-derived macrophage activating factor it is a Macrophage Activating Factor (MAF) that has been tested for use as a cancer treatment that would activate macrophages against cancer cells. [10]
Sunbaker, by Max Dupain. Exposure of skin to ultraviolet radiation from sunlight presents both positive and negative health effects. On the positive side, UV exposure enables the synthesis of vitamin D 3, which is essential for bone health [1] and potentially plays a role in inhibiting certain cancers.
Cholecalciferol, also known as vitamin D 3 or colecalciferol, is a type of vitamin D that is produced by the skin when exposed to UVB light; it is found in certain foods and can be taken as a dietary supplement. [3] Cholecalciferol is synthesised in the skin following sunlight exposure. [4]
Synthesis of pre-vitamin D 3 in the skin involves UVB radiation, which effectively penetrates only the epidermal layers of skin. 7-Dehydrocholesterol absorbs UV light most effectively at wavelengths between 295 and 300 nm and, thus, the production of vitamin D 3 will occur primarily at those wavelengths. [8]
2. Vitamin B12. One of eight B-complex vitamins, vitamin B12 is found naturally in some types of fish, red meat and fortified foods.It plays a key role in central nervous system function, DNA ...
Even high-SPF sunscreens allow a small amount of UVB to reach the skin, sufficient for vitamin D synthesis. Additionally, brief, unprotected sun exposure can produce ample vitamin D, but this exposure also risks significant DNA damage and skin cancer. To avoid these risks, vitamin D can be obtained safely through diet and supplements.
Previtamin D 3 is an intermediate in the production of cholecalciferol (vitamin D 3). It is formed by the action of UV light, most specifically UVB light of wavelengths between 295 and 300 nm, acting on 7-dehydrocholesterol in the epidermal layers of the skin. [1] [2] [3] The B ring of the steroid nucleus structure is broken open, making a ...
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