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Phage therapy has many potential applications in human medicine as well as dentistry, veterinary science, and agriculture. [20] If the target host of a phage therapy treatment is not an animal, the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy". [9]
Although phages do not infect humans, there are countless phage particles in the human body, given the extensive human microbiome. One's phage population has been called the human phageome, including the "healthy gut phageome" (HGP) and the "diseased human phageome" (DHP). [105] The active phageome of a healthy human (i.e., actively replicating ...
Phage therapy has gained recent attention in the United States as an alternative to standard antibiotic therapy. [ 5 ] [ 6 ] [ 7 ] It has been in practice for just over 100 years in countries such as Russia and Georgia , but due to the recent clinical attention of antibiotic resistance , Western countries have slowly been integrating phage ...
Mycobacteriophage Bxb1 Structure [1]. A mycobacteriophage is a member of a group of bacteriophages known to have mycobacteria as host bacterial species. While originally isolated from the bacterial species Mycobacterium smegmatis and Mycobacterium tuberculosis, [2] the causative agent of tuberculosis, more than 4,200 mycobacteriophage species have since been isolated from various environmental ...
“Phage cocktails” are a form of phage therapy that involves employing at least two phages to target a single bacterial strain, [13] creating a form of therapy with greater ‘depth.’ Phage cocktails are an effective substitute for antibiotics as they create a broader host range and delay the development of phage resistance in bacteria ...
Phageome research in humans has largely focused on the gut, however it is also being investigated in other areas like the skin, [8] blood, [9] and mouth. [10] The composition of phages that make up a healthy human gut phageome is currently debated, since different methods of research can lead to different results. [11]
Stomach pain or tummy troubles are among the most common ailments that affect children and adults alike. Feelings of bloating, cramping, constipation or nausea often occur because of something ...
After this successful experiment on chicken, he felt ready for the first trial on humans. The first patient was healed of dysentery using phage therapy in August 1919. Many more followed. At the time, none, not even d'Hérelle, knew exactly what a phage was.