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Domperidone, sold under the brand name Motilium among others, is a dopamine antagonist medication which is used to treat nausea and vomiting and certain gastrointestinal problems like gastroparesis (delayed gastric emptying). It raises the level of prolactin in the human body and is used off label to induce and promote breast milk production.
A galactagogue, or galactogogue (from Greek: γάλα [γαλακτ-], milk, + ἀγωγός, leading), also known as a lactation inducer or milk booster, is a substance that promotes lactation in humans and other animals. [1] [2] It may be synthetic, plant-derived, or endogenous. They may be used to induce lactation and to treat low milk supply.
Most recently a subject of transgender health care, multiple case reports have described transgender women successfully inducing lactation. [26] [27] Research has indicated that such breast milk is nutritionally comparable to both the milk of naturally lactating and induced lactating cisgender women. [28] Domperidone is a drug that can induce ...
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Galactogogues such as the peripherally selective D 2 receptor antagonist and prolactin releaser domperidone can be used to induce lactation in transgender women who wish to breastfeed. [273] [274] [65] An extended period of combined estrogen and progestogen therapy is necessary to mature the lobuloalveolar tissue of the breasts before this can ...
Whereas D 2 receptor agonists suppress prolactin secretion, dopamine D 2 receptor antagonists like domperidone and metoclopramide have the opposite effect, strongly inducing the pituitary secretion of prolactin, and are sometimes used as prolactin releasers, for instance to correct hypoprolactinemia (low prolactin levels) in the treatment of lactation failure. [2]
5617 19109 Ensembl ENSG00000172179 ENSMUSG00000021342 UniProt P01236 P06879 RefSeq (mRNA) NM_000948 NM_001163558 NM_001163530 NM_011164 RefSeq (protein) NP_000939 NP_001157030 NP_001157002 NP_035294 Location (UCSC) Chr 6: 22.29 – 22.3 Mb Chr 13: 27.24 – 27.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Prolactin (PRL), also known as lactotropin and mammotropin, is a protein ...
Domperidone [d] Motilium: Prolactin releaser: Oral: 30–80 mg/day [e Template documentation. See also. Template:Estrogen dosages for menopausal hormone therapy ...