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Warning label on a tube of rat poison containing bromadiolone on a dike of the Scheldt river in Steendorp, Belgium. Bromadiolone is a potent anticoagulant rodenticide.It is a second-generation 4-hydroxycoumarin derivative and vitamin K antagonist, often called a "super-warfarin" for its added potency and tendency to accumulate in the liver of the poisoned organism.
Brodifacoum is a 4-hydroxycoumarin anticoagulant, with a similar mode of action to its historical predecessors dicoumarol and warfarin.However, due to very high potency and long duration of action (elimination half-life of 20 – 130 days), it is characterised as a "second-generation" or "superwarfarin" anticoagulant.
The second-generation vitamin K antagonist agents, used only in this fashion as poisons (because their duration of action is too long to be used as pharmaceuticals) include: coumatetralyl; difenacoum; flocoumafen; bromadiolone; tioclomarol; brodifacoum ("d-CON" etc.)
bromadiolone [4] difenacoum [5] auraptene; ensaculin; phenprocoumon (Marcoumar) PSB-SB-487; PSB-SB-1202; scopoletin can be isolated from the bark of Shorea pinanga [6] warfarin (Coumadin) Coumarin is transformed into the natural anticoagulant dicoumarol by a number of species of fungi. [7]
However, the main excitable cell is the neuron, which also has the simplest mechanism for the action potential. [citation needed] Neurons are electrically excitable cells composed, in general, of one or more dendrites, a single soma, a single axon and one or more axon terminals. Dendrites are cellular projections whose primary function is to ...
A mechanism of action of a chemical could be "binding to DNA" while its broader mode of action would be "transcriptional regulation". [3] However, there is no clear consensus and the term mode of action is also often used, especially in the study of pesticides, to describe molecular mechanisms such as action on specific nuclear receptors or ...
A "strong person of interest" was arrested in Pennsylvania on Monday, after finding he had a fake ID with the same name as the one used by the suspected killer of UnitedHealthcare CEO Brian ...
In some literature articles, the terms "mechanism of action" and "mode of action" are used interchangeably, typically referring to the way in which the drug interacts and produces a medical effect. However, in actuality, a mode of action describes functional or anatomical changes, at the cellular level, resulting from the exposure of a living ...