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Inhalable insulin is a powdered form of insulin, delivered with an inhaler into the lungs where it is absorbed. [1] In general, inhaled insulins have been more rapidly absorbed than subcutaneous injected insulin, with faster peak concentration in serum and more rapid metabolism.
The combination is approved in the United States only as a maintenance medication in asthma and chronic obstructive pulmonary disease (COPD). [2] However, a 2020 review of the literature does support use as needed during acute worsening in those with mild disease, and as maintenance followed by extra doses during worsening.
Pulmonary drug delivery is mainly utilized for topical applications in the lungs, such as the use of inhaled beta-agonists, corticosteroids and anticholinergic agents for the treatment of asthma and COPD, the use of inhaled mucolytics and antibiotics for the treatment of cystic fibrosis (CT) and respiratory viral infections, [1] and the use of inhaled prostacyclin analogs for the treatment of ...
MannKind has been struggling to get its inhalable insulin product Afrezza on the market; the product was sent back to the labs by the Food and Drug Administration in 2011 for further trials.
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Currently, inhaled insulin is short-acting and is typically taken before meals; an injection of long-acting insulin at night is often still required. [108] When people were switched from injected to inhaled insulin, no significant difference was observed in Hb A1c levels over three months. Accurate dosing was a particular problem, although ...
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