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Most individuals with G6PD deficiency are asymptomatic.When it induces hemolysis, the effect is usually short-lived. [5]Most people who develop symptoms are male, due to the X-linked pattern of inheritance, but female carriers can be affected due to unfavorable lyonization or skewed X-inactivation, where random inactivation of an X-chromosome in certain cells creates a population of G6PD ...
G6PD converts G6P into 6-phosphoglucono-δ-lactone and is the rate-limiting enzyme of the pentose phosphate pathway. Thus, regulation of G6PD has downstream consequences for the activity of the rest of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is stimulated by its substrate G6P.
People suffering from 6PGD or G6PD deficiency (or both) are at risk of hemolytic anemia in states of oxidative stress. Oxidative stress can result from infection and from chemical exposure to medication and certain foods. Broad beans, e.g., fava beans, contain high levels of vicine, divicine, convicine and isouramil, all of which are oxidants.
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Various genetic studies on Filipinos have been performed, to analyze the population genetics of the various ethnic groups in the Philippines.. The results of a DNA study conducted by the National Geographic's "The Genographic Project", based on genetic testings of Filipino people by the National Geographic in 2008–2009, found that the Philippines is made up of around 53% Southeast Asia and ...
The Philippines, [f] officially the Republic of the Philippines, [g] is an archipelagic country in Southeast Asia. In the western Pacific Ocean, it consists of 7,641 islands, with a total area of roughly 300,000 square kilometers, which are broadly categorized in three main geographical divisions from north to south: Luzon, Visayas, and Mindanao.
A U.S. Border Patrol officer deploys a flare while blocking Interstate 91 southbound, a day after a U.S. Border Patrol officer was shot and killed on the highway in Coventry, Vermont, on January ...
The 50 largest islands have a combined area of around 321,000 square kilometers (124,000 sq mi) and a combined population of about 100.9 million (2015); thus they contain about 99% of the Philippines' total land area and total population (2015). Combined population of Luzon and Mindanao accounts for 80% of total population of the Philippines.