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Without proper treatment the severity increases as the thickened material can cause obstruction in the bile ducts. This results in the risk of gallbladder rupture which is life-threatening thus early diagnosis is necessary. [8] Additionally the composition of biliary sludge has been suggested to encourage the formation of a mucocele.
Maropitant undergoes 1st-pass metabolism by liver enzymes, mainly CYP2D15 (which has high affinity for maropitant and clears over 90% of it) but also by the lower-affinity CYP3A12. [ 11 ] [ 12 ] Repeat dosing of maropitant eventually saturates CYP2D15, causing the drug to accumulate due to reduced clearance. [ 5 ]
Acetaminophen (paracetamol, Tylenol) can cause liver damage in dogs. The toxic dose is 150 mg/kg. [174] Ibuprofen * can cause gastrointestinal irritation, stomach ulcers, and kidney damage in dogs. [175] Naproxen (Aleve)* has a long half-life in dogs and can cause gastrointestinal irritation, anemia, melena (digested blood in feces), and vomiting.
It should not be prescribed to dogs with blood disorders, such as anemia, or liver or kidney disease, VCA said. The other concern with chloramphenicol is its toxicity to humans, experts tell ...
In most cases, appropriate treatment protocols cause few side effects, but white blood cell counts must be monitored. Allogeneic and autologous stem cell transplantations (as is commonly done in humans) have recently been shown to be a possible treatment option for dogs. [19] Most of the basic research on transplantation biology was generated ...
Although dog treats carry high benefits for dogs' teeth, they can also be a source of problems like obesity when given excessively, especially human table scraps. The type of food given directly affects the tendency of a dog to become overweight. Table scraps, treats, and even premium high-energy dog foods can contribute to obesity. [68]
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