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Metabolife International, Inc. was a multi-level marketing company based in San Diego, California which manufactured dietary supplements.Metabolife's best-selling product, an ephedra supplement called Metabolife 356, once generated hundreds of millions of dollars in annual sales. [1]
Chemins was the manufacturer of dietary supplements for the multi-level marketing companies Metabolife (i.e., Metabolife 356, an ephedra-based supplement that was withdrawn following numerous adverse event reports) [4] [5] and LifeVantage (i.e., Protandim, an herbal-based supplement). [6] Chemins' assets were acquired by Nexgen Pharma in 2007. [7]
Ephedra is widely used by athletes as a performance-enhancing drug, [13] despite a lack of evidence that it improves athletic performance. [14] [15] Ephedra may also be used as a precursor in the illicit manufacture of methamphetamine. [16] Ephedra has been used as a weight-loss aid, sometimes in combination with aspirin and caffeine.
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In the United States, it is illegal to market products containing ephedrine or ephedra alkaloids as a dietary supplement. [1] In 2004, ephedra, a botanical source of ephedrine alkaloids, was banned by the U.S. Food and Drug Administration due to serious safety concerns, injuries, and deaths linked to ephedra-containing supplements. However ...