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As per Falkow's original descriptions, the three postulates are: [1] "The phenotype or property under investigation should be associated with pathogenic members of a genus or pathogenic strains of a species. Specific inactivation of the gene(s) associated with the suspected virulence trait should lead to a measurable loss in pathogenicity or ...
Falkow is known as the father of the field of molecular microbial pathogenesis. [1] He formulated molecular Koch's postulates, which have guided the study of the microbial determinants of infectious diseases since the late 1980s. [2] Falkow spent over 50 years uncovering molecular mechanisms of how bacteria cause disease and how to disarm them. [1]
In 1988, microbiologist Stanley Falkow developed a set of three Molecular Koch's postulates for identifying the microbial genes encoding virulence factors. First, the phenotype of a disease symptom must be associated with a specific genotype only found in pathogenic strains. Second, that symptom should not be present when the associated gene is ...
Microbial pathogenesis is a field of microbiology that started at least as early as 1988, with the identification of the triune Falkow's criteria, aka molecular Koch's postulates.
Hamilton Othanel Smith (born August 23, 1931 in New York) [1] is an American microbiologist and Nobel laureate. [ 2 ] [ 3 ] Smith graduated from University Laboratory High School of Urbana, Illinois .
Michael Smith CC OBC FRS [1] (April 26, 1932 – October 4, 2000) was a British-born Canadian biochemist and businessman. He shared the 1993 Nobel Prize in Chemistry [3] with Kary Mullis for his work in developing site-directed mutagenesis.
Stanley Falkow (1934–2018), US microbial geneticist, molecular mechanisms of bacterial pathogenesis; Harold Falls (1909–2006), US ophthalmologic geneticist, helped found first genetics clinic in US; William C. Farabee (1865–1925), US anthropologist, brachydactyly is evidence of Mendelism in humans
Alexander Graham Cairns-Smith FRSE (24 November 1931 – 26 August 2016) was an organic chemist and molecular biologist at the University of Glasgow. [1] He studied at the University of Edinburgh, where he gained a Ph.D. in Chemistry (1957). [2] He was most famous for his controversial 1985 book Seven Clues to the Origin of Life.