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Flammer syndrome is a described clinical entity comprising a complex of clinical features caused mainly by dysregulation of the blood supply. It was previously known as vascular dysregulation. [1] It can manifest in many symptoms, such as cold hands and feet, and is often associated with low blood pressure.
The hands typically get cold when the body or the hand specifically is exposed to cold.” Most of the time cold hands aren’t a cause for concern — they’re simply the result of less blood ...
Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
The condition can cause localized pain, discoloration (paleness), and sensations of cold and/or numbness. When exposed to cold temperatures, the blood supply to the fingers or toes, and in some cases the nose or earlobes, is markedly reduced; the skin turns pale or white (called pallor) and becomes cold and numb.
A common complaint among patients with cold agglutinin disease is painful fingers and toes with purplish discoloration associated with cold exposure. In chronic cold agglutinin disease, the patient is more symptomatic during the colder months. Cold agglutinin-mediated acrocyanosis differs from Raynaud phenomenon.
Livedo reticularis is a common skin finding consisting of a mottled reticulated vascular pattern that appears as a lace-like purplish discoloration of the skin. [1] The discoloration is caused by reduction in blood flow through the arterioles that supply the cutaneous capillaries, resulting in deoxygenated blood showing as blue discoloration ().
It was thought that the hunting reaction protected the fingers against cold injury and improved muscle function in the fingers. An experiment has shown cold acclimation minimizes the hunting reaction (reduced mean temperature of the digits and a prolonged time of cold exposure prior to initial vasodilation), thus putting the hand at a greater ...
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