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N-acetylphosphatidylethanolamine-hydrolysing phospholipase D (EC 3.1.4.54, NAPE-PLD, anandamide-generating phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, NAPE-hydrolyzing phospholipase D) is an enzyme with systematic name N-acetylphosphatidylethanolamine phosphatidohydrolase. [1] [2] It catalyses the following chemical reaction
A hydrophobic cavity in NAPE-PLD provides an entryway for the substrate NAPE into the active site, where a binuclear zinc center orchestrates its hydrolysis. Unexpectedly, the structure unveils bile acids bind the membrane enzyme, enhancing dimer assembly and enabling catalysis.
N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) is an enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE). This is a major part of the process that converts ordinary lipids into chemical signals like anandamide and oleoylethanolamine .
In traditional Japanese culture, the nape (項, unaji) was one of the few areas of the body (other than face and hands) left uncovered by women's attire. The nape of a woman's neck held a strong attraction for many Japanese men (see oshiroi). [2] In Egyptian and Lebanese culture, slapping the nape is considered a gesture of utter humiliation. [3]
Nape 'a Motana (born 1945), South African writer; Nape Nnauye, 21st century Tanzanian politician; David Nape (1870–1913), composer, member of the Royal Hawaiian Band, inducted into the Hawaiian Music Hall of Fame; Jeffery Nape (1964–2016), Speaker of the National Parliament and Governor-General of Papua New Guinea
Klippe of Hronic nappe, Mt. Vápeč, Strážovské vrchy Mts., Slovakia. Nappe can be qualified in a number of ways to indicate various features of a formation. The frontal part in the direction of movement, is called the leading edge of a nappe; numerous folds and secondary thrusts and duplexes are common features here and are sometimes called digitations.
The bald eagle had been on the nation’s Great Seal since the Revolutionary War, but it was never codified in law as the official bird.
Many pathways of water can enter through a dam structure to produce a well-defined nappe. However, engineers classify dams as either overflow dams, where water consistently flows over or is blocked through a gate on top of crest, or non-overflow dams, which channel water through or around the dam with emergency floodgates.