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A peptidomimetic is a small protein-like chain designed to mimic a peptide. [ 1 ] [ 2 ] They typically arise either from modification of an existing peptide, or by designing similar systems that mimic peptides, such as peptoids and β-peptides .
Prohibitin-targeting peptide 1 (also known as prohibitin-TP01 and TP01; trade name Adipotide) is a peptidomimetic with sequence CKGGRAKDC-GG-D (KLAKLAK) 2.It is an experimental proapoptotic drug [1] that has been shown to cause rapid weight loss in mice [2] and rhesus monkeys. [3]
6564 56643 Ensembl ENSG00000088386 ENSMUSG00000025557 UniProt P46059 Q9JIP7 RefSeq (mRNA) NM_005073 NM_053079 RefSeq (protein) NP_005064 NP_444309 Location (UCSC) Chr 13: 98.68 – 98.75 Mb Chr 14: 121.7 – 121.74 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse PepT 1 is a proton-coupled peptide cotransporter in epithelial cells. Peptide transporter 1 (PepT 1) also known as solute ...
[7] [8] The largest groups of peptidomimetic consist of β-peptides, γ-peptides and δ-peptides, and the possible monomeric combinations. [8] The amino acids of these peptides only differ by one (β), two (γ), or three (δ) methylene carbons, yet the structural changes were profound. These peptide sequences are highly studied as sequence ...
There are a number of different distinct classes of protein mimetics. Antibody mimetic - Molecules that mimic antigen binding activity of antibodies; Peptidomimetic - Small protein-like chains designed to mimic larger peptide.
A stapled peptide is a modified peptide (class A peptidomimetic), typically in an alpha-helical conformation, [2] that is constrained by a synthetic brace ("staple"). [3] The staple is formed by a covalent linkage between two amino acid side-chains, forming a peptide macrocycle. Staples, generally speaking, refer to a covalent linkage of two ...
The traditional vaccines are the whole live or fixed pathogens. The second generation of vaccines is mainly the protein purified from the pathogen. The third generation of vaccines is the DNA or plasmid that can express the proteins of the pathogen.
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