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There is little modern clinical research on Dioscorea villosa, and the one study of a wild yam-containing cream for menopausal symptoms failed to find any value from this therapy. [18] According to the American Cancer Society , there is no evidence to support wild yam or diosgenin being either safe or effective in humans.
Creams. Conjugated estrogens (Premarin) – 0.625 mg/g (0.0625%) ... For Women: Menopause—Medicines to Help You – U.S. Food and Drug Administration
[2]: 1346 [10] Diosgenin, which is present in fenugreek and wild yam, affected maturation, but that wasn't enough evidence for this indication. [2]: 1347 Some medications have been involved in breast enlargement as a side effect. [2] [8]
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Average number of moderate-to-severe hot flashes per week with placebo and different doses of oral estradiol in menopausal women [40] [41]. Estradiol is used in menopausal hormone therapy to prevent and treat moderate to severe menopausal symptoms such as hot flashes, vaginal dryness and atrophy, and osteoporosis (bone loss). [11]
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