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Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. There are two major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse ...
Since this activity occurs in the nucleus of the cell ATA is a form of antinuclear antibody. Scleroderma results from the overproduction of collagen in affected tissues, one study claims that there is an increased density of Topoisomerase I sites in the collagen genes, and that the antibodies may be altering transcription at these loci. [7]
In cell biology, there are a multitude of signalling pathways. Cell signalling is part of the molecular biology system that controls and coordinates the actions of cells. Akt/PKB signalling pathway
Primary lateral sclerosis, progressive muscle weakness in the voluntary muscles. Primary sclerosing cholangitis, a hardening of the bile duct by scarring and repeated inflammation. Systemic sclerosis (progressive systemic scleroderma), a rare, chronic disease which affects the skin, and in some cases also blood vessels and internal organs.
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events.Proteins responsible for detecting stimuli are generally termed receptors, although in some cases the term sensor is used. [1]
CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc), is a multisystem connective tissue disorder. The acronym "CREST" refers to the five main features: calcinosis , Raynaud's phenomenon , esophageal dysmotility , sclerodactyly , and telangiectasia .
One team has already joined the NFL playoff picture in Week 16, and a few more could be on the way. Here are the clinching scenarios remaining.
This pathway or communication is referred to as the cervical sympathetic trunk-submandibular gland (CST-SMG) axis, a regulatory system that plays a role in the systemic control of inflammation. [ 4 ] Cellular Effects of feG: The cellular effects of the ImSAIDs are characterized in a number of publications.