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Glyphosate (IUPAC name: N-(phosphonomethyl)glycine) is a broad-spectrum systemic herbicide and crop desiccant.It is an organophosphorus compound, specifically a phosphonate, which acts by inhibiting the plant enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSP).
The glyphosate-based herbicide RoundUp (styled: Roundup) was developed in the 1970s by Monsanto. Glyphosate was first registered for use in the U.S. in 1974. [4] Glyphosate-based herbicides were initially used in a similar way to paraquat and diquat, as non-selective herbicides. Attempts were made to apply them to row crops, but problems with ...
Glyphosate, the herbicidal ingredient in Roundup, is a competitive inhibitor of EPSP synthase, acting as a transition state analog that binds more tightly to the EPSPS-S3P complex than PEP and inhibits the shikimate pathway. Then 5-enolpyruvylshikimate-3-phosphate is transformed into chorismate by a chorismate synthase.
Glyphosate, a commonly used herbicide, is an inhibitor of 5-enolpyruvylshikimate 3-phosphate synthase or EPSP synthase, an enzyme in the shikimate pathway. The problem is that this herbicide has been utilized for about 20 years and now some plants have now emerged that are glyphosate-resistant.
Glyphosate was found in 5–15% of cereal crop samples tested in the UK between 2000 and 2004, although never exceeding the Maximum Residue Level of 20 mg/kg. [22] A survey of British wheat in 2006-2008 found average levels of 0.05–0.22 mg/kg with maximum levels of 1.2 mg/kg.
EPSP synthase is the biological target for the herbicide glyphosate. [13] Glyphosate is a competitive inhibitor of EPSP synthase, acting as a transition state analog that binds more tightly to the EPSPS-S3P complex than PEP and inhibits the shikimate pathway .
A 2008–2009 survey of 144 populations of waterhemp in 41 Missouri counties revealed glyphosate resistance in 69%. Weeds from some 500 sites throughout Iowa in 2011 and 2012 revealed glyphosate resistance in approximately 64% of waterhemp samples. As of 2023, 58 weed species have developed glyphosate resistance. [70]
The Herbicide Resistance Action Committee (HRAC) classifies herbicides by their mode of action (MoA) to provide a uniform way for farmers and growers to identify the agents they use and better manage pesticide resistance around the world.