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ETS1 binds with DNA-dependent protein kinase (DNA-PK) [where the DNA-PK complex is made up of DNA-PKcs and DNA repair Ku (protein), and where Ku itself is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5)]. [17] ETS1 interaction with DNA-PK phosphorylates ETS1. [17] Such phosphorylation of ETS1 alters its target gene repertoire. [18]
There are 28 genes in humans, [4] 27 in the mouse, 10 in Caenorhabditis elegans and 9 in Drosophila. The founding member of this family was identified as a gene transduced by the leukemia virus, E26. The members of the family have been implicated in the development of different tissues as well as cancer progression.
Using this technique, it is possible to locate gene expression to specific cell types in specific regions and observe how changes in this distribution occur throughout the development and correlate with the behavioral manipulations. [5] Examples of markers that are expressed in different stages of neurogenesis in adult hippocampus.
9935 16658 Ensembl ENSG00000204103 ENSMUSG00000074622 UniProt Q9Y5Q3 P54841 RefSeq (mRNA) NM_005461 NM_010658 RefSeq (protein) NP_005452 NP_034788 Location (UCSC) Chr 20: 40.69 – 40.69 Mb Chr 2: 160.21 – 160.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor MafB also known as V-maf musculoaponeurotic fibrosarcoma oncogene homolog B is a protein that in ...
The authors propose that miR-1 and miR-133a act to repress isoforms of genes that are not normally expressed in muscle cells. All of these observations suggest that mis-regulation of miR-1 and miR-133a can result in tumorogenesis via abolition of the suppressive effect they have on certain gene targets and of the removal of the promotion of ...
C11orf49 is a protein coding gene that in humans encodes for the C11orf49 protein. [5] It is heavily expressed in brain tissue and peripheral blood mononuclear cells, with the latter being an important component of the immune system.
Gene ID DBD Motif status (Feb 2018) (Link to human TFs annotation) IUPAC consensus (from selected PWM) AC008770.3: ENSG00000267179: C2H2 ZF: Likely sequence specific TF according to literature or domain structure – No motif : AC023509.3: ENSG00000267281: bZIP: Known motif – from protein with 100% identical DBD – in vitro : RTGACGTCAY ...
If these CpG islands in ETS1 binding sites of the PARP1 promoter are epigenetically hypomethylated, PARP1 is expressed at an elevated level. [23] [24] Cells from older humans (69 to 75 years of age) have a constitutive expression level of both PARP1 and PARP2 genes reduced by half, compared to their levels in young adult humans (19 to 26 years ...
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