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2. Pamrevlumab - Wikipedia

   en.wikipedia.org/wiki/Pamrevlumab

   Pamrevlumab (INN; [1] development code FG-3019) is a humanized monoclonal antibody designed for the treatment of idiopathic pulmonary fibrosis and pancreatic cancer. It binds to the connective tissue growth factor (CTGF) protein. [2] This drug was developed by FibroGen, Inc. [3]

3. FibroGen's lung disease drug fails late-stage trial, shares tank

   www.aol.com/news/fibrogens-drug-fails-stage...

   The drug, pamrevlumab, was being tested for idiopathic pulmonary fibrosis (IPF), which causes build up of scar tissue in the lungs, making them unable to transport oxygen into the bloodstream ...

4. List of therapeutic monoclonal antibodies - Wikipedia

   en.wikipedia.org/wiki/List_of_therapeutic...

   Pamrevlumab [12] mab: human: connective tissue growth factor (CTGF) idiopathic pulmonary fibrosis (IPF), pancreatic cancer Panitumumab [69] Vectibix: mab: human: epidermal growth factor receptor (EGFR) Y: colorectal cancer: Pankomab: mab: humanized: tumor specific glycosylation of MUC1: ovarian cancer Panobacumab [98] mab: human: Pseudomonas ...

5. CTGF - Wikipedia

   en.wikipedia.org/wiki/CTGF

   14219 Ensembl ENSG00000118523 ENSMUSG00000019997 UniProt P29279 P29268 RefSeq (mRNA) NM_001901 NM_010217 RefSeq (protein) NP_001892 NP_034347 Location (UCSC) Chr 6: 131.95 – 131.95 Mb Chr 10: 24.47 – 24.47 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular ...

6. ‘My Low Back Pain Turned Out To Be A Rare Inflammatory ...

   www.aol.com/low-back-pain-turned-rare-120000344.html

   They might also be at risk for fibrosis in the lungs, along with a rare neurological condition called cauda equina syndrome due to the scarring of nerves at the base of the spine.

7. Merck's therapy for rare lung condition shown to help reduce ...

   www.aol.com/news/mercks-therapy-rare-lung...

   Winrevair was approved to treat pulmonary arterial hypertension (PAH), a progressive disorder caused by a constriction of arteries in the lungs, leading to symptoms such as shortness of breath ...

8. Fresolimumab - Wikipedia

   en.wikipedia.org/wiki/Fresolimumab

   It is intended for the treatment of idiopathic pulmonary fibrosis (IPF), focal segmental glomerulosclerosis, and cancer [2] [3] (kidney cancer and melanoma). It binds to and inhibits all isoforms of the protein transforming growth factor beta (TGF-β).

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