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Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune disease of the liver. [ 1 ] [ 2 ] [ 3 ] It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver, a condition called cholestasis .
The differential diagnosis can include primary biliary cholangitis (formerly referred to as primary biliary cirrhosis), drug-induced cholestasis, cholangiocarcinoma, IgG4-related disease, post-liver transplantation nonanastomotic biliary strictures, [23] and HIV-associated cholangiopathy. [24]
Anti-mitochondrial antibodies (AMA) are autoantibodies, consisting of immunoglobulins formed against mitochondria, [1] primarily the mitochondria in cells of the liver.. The presence of AMA in the blood or serum of a person may be indicative of the presence of, or the potential to develop, the autoimmune disease primary biliary cholangitis (PBC; previously known as primary biliary cirrhosis).
Bile duct obstruction, which is usually present in acute cholangitis, is generally due to gallstones. 10–30% of cases, however, are due to other causes such as benign stricturing (narrowing of the bile duct without an underlying tumor), postoperative damage or an altered structure of the bile ducts such as narrowing at the site of an anastomosis (surgical connection), various tumors (cancer ...
What it is: A group of bacteria that can cause gastrointestinal illness. It’s typically associated with meat and poultry as well as undercooked eggs, but dairy products, fruits and leafy greens ...
Also known as the stomach flu or bug, norovirus often triggers painful gastrointestinal symptoms as well as fever, aches and headaches within days of exposure. 7 common stomach flu symptoms you ...
Eating spicy food, especially in large quantities, can cause gastrointestinal distress, heartburn, acid reflux, vomiting or diarrhea. "The GI distress tends to be more common in people who have ...
Positive symptoms include biliary colic, acute pancreatitis, obstructive jaundice and less commonly, liver enlargement and abnormal liver function tests. [1] Additional complications in the acute setting include ascending cholangitis , gallbladder empyema , clotting within the hepatic and portal veins , sepsis and death.