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Sulfasalazine metabolizes to sulfapyridine. Serum levels should be monitored every three months, and more frequently at the outset. Serum levels above 50 μg/L are associated with side effects. In rare cases, sulfasalazine can cause severe depression in young males. It can also cause oligospermia and temporary infertility.
Sulfapyridine levels above 50 μg/L are associated with the side-effects. Patients on high dose sulfasalazine require folic supplementation (1 mg/day) (1000 μg/day) to maintain normal cell division. This may, however, be counter-productive for patients who are also taking methotrexate, which is a folic acid inhibitor.
This and the lack of testing requirements led to the elixir sulfanilamide disaster in the fall of 1937, during which at least 100 people were poisoned with diethylene glycol. This led to the passage of the Federal Food, Drug, and Cosmetic Act in 1938 in the United States, giving authority to the U.S. Food and Drug Administration (FDA) to ...
Dangerous side effects from the injectable canine drug Librela — used to treat osteoarthritis joint pain — have been linked to seizures, lameness and loss of muscle control, the FDA warned.
The post Apoquel for Dogs: Uses, Dosage, & Side Effects appeared first on DogTime. ... The medication comes in oral tablet and chewable tablet forms in different strengths — 3.6 mg, 5.4 mg, and ...
It has also been used as a second line agent to sulfasalazine in people with inflammatory bowel disease such as ulcerative colitis and Crohn's disease. [3] It is typically taken by mouth. [3] Common side effects include nausea, abdominal pain, and diarrhea. [3] Other side effects may include liver inflammation and allergic reactions. [3]
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