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Diphenhydramine, while traditionally known as an antagonist, acts primarily as an inverse agonist of the histamine H 1 receptor. [86] It is a member of the ethanolamine class of antihistaminergic agents. [45] By reversing the effects of histamine on the capillaries, it can reduce the intensity of allergic symptoms.
An acute anticholinergic syndrome is reversible and subsides once all of the causative agents have been excreted. Reversible acetylcholinesterase inhibitor agents such as physostigmine can be used as an antidote in life-threatening cases. Wider use is discouraged due to the significant side effects related to cholinergic excess including ...
Medications are used to reverse the symptoms of extrapyramidal side effects caused by antipsychotics or other drugs, by either directly or indirectly increasing dopaminergic neurotransmission. The treatment varies by the type of the EPS, but may involve anticholinergic agents such as procyclidine, benztropine, diphenhydramine, and trihexyphenidyl.
Benadryl Allergy. Benadryl Allergy is the name of a Benadryl product found in the United States and Canada. It is an antihistamine drug used to relieve allergies. Its active ingredient is diphenhydramine, a first-generation antihistamine. It is known to be sedative, making drowsiness a common side effect.
t. e. Benzodiazepine overdose (BZD OD) describes the ingestion of one of the drugs in the benzodiazepine class in quantities greater than are recommended or generally practiced. The most common symptoms of overdose include central nervous system (CNS) depression, impaired balance, ataxia, and slurred speech.
Physostigmine (also known as eserine from éséré, the West African name for the Calabar bean) is a highly toxic parasympathomimetic alkaloid, specifically, a reversible cholinesterase inhibitor. It occurs naturally in the Calabar bean and the fruit of the Manchineel tree. The chemical was synthesized for the first time in 1935 by Percy Lavon ...
Antidote. An antidote is a substance that can counteract a form of poisoning. [1] The term ultimately derives from the Greek term φάρμακον ἀντίδοτον (pharmakon antidoton), " (medicine) given as a remedy". Antidotes for anticoagulants are sometimes referred to as reversal agents.
Protamine sulfate replaced hexadimethrine bromide (Polybrene), another cationic agent that was the original heparin reversal agent in the early days of heart surgery, until studies in the 1960s suggested that hexadimethrine bromide might cause kidney failure when used in doses in excess of its therapeutic range. [21]
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