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Photographer: Ed Heffron, Brice Critser, CRA. Lisch nodules are melanocytic hamartomas of the iris, often associated with neurofibromatosis (NF) I. They are usually elevated and tan in appearance. Their incidence in NF1 increases with age and their prevalence raises by about 10% per year of life, up to age 9. These photographs show the various ...
Neurofibromatosis type 1 (NF-1) Lisch Nodules. 1) Lisch Nodules on iris. 2) NF on face. NF on arm. Other systemic manifestations include: Cafe au Lait Spots and optic nerve gliomas. Ophthalmic Atlas Images by EyeRounds.org, The University of Iowa are licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
For the ophthalmologist, NF1 may present with a variety of ophthalmic manifestations. Lisch nodules (melanocytic nevi of the iris and uveal tract) are the most common finding. Development of a plexiform neurofibroma within the lid can cause a classic S-shaped ptosis in the pediatric patient. Optic nerve gliomas occur in 12% of patients with NF1 ...
Title: Atlas Entry - Lisch nodules Author: brettjohnson Created Date: 8/15/2019 1:41:30 PM
This is a 78-year-old man with neurofibromatosis type 1. He has multiple Lisch nodules. He was diagnosed with open angle glaucoma at age 74. Courtesy of Young H. Kwon, MD, PhD. The University of Iowa.
Iris mammillations are diffuse, tiny, nodules that cover the iris surface. They are most commonly unilateral and are usually seen in darkly pigmented irides or overlying iris nevi. Mammillations can be associated with oculodermal melanocytosis or phakomatosis pigmentovascularis (PPV) type IIb and neurofibromatosis (NF) type I. They are usually ...
The classic Cogan-Reese nodules, which result from melanocytic proliferation within the iris stroma, are present on the anterior surface of the iris, appear late in the disease, and become darker and larger over time [6]. While these nodules are typically described as diffuse, it is possible for only a segment of the iris to be affected.
Photographer: Antoinette Venckus, CRA. Kunkmann-Wolffian bodies are hypopigmented areas of peripheral iris stromal hyperplasia in patients without Down syndrome. They are clinically indistinguishable from Brushfield spots which are seen in individuals with Down syndrome. Enlarge Download.
In 2006 he was noted to have an intraocular pressure of 34 mmHg in the right eye. On examination he has 20/40 vision in the right eye and 20/20 vision in the left eye. His intraocular pressure on three medications is 12 mmHg OD and 8 mmHg OS. The right eye has corectopia and iris nodules.
Nodules are annular in the mid-periphery. Figure 8b: Slit lamp photo of the left eye of another patient with Salzmann's nodular corneal degeneration. Nodules are annular in the interior mid-periphery. Figure 8c: Corneal topography. The right eye shows a very irregular astigmatism with superior and nasal steepening.