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  2. Does tumor location affect prostate cancer prognosis?

    ascopubs.org/doi/10.1200/JCO.2019.37.7_suppl.45

    Among the subzones, the highest 5Y-PSAFR was seen in B3, followed by M6, B2, T4, A3, and the lowest was seen in M4, A2, T2, A1 in that order. A multivariate analysis for PSAF risk among subzones showed that B3 (HR 8.6, p <0.0001) and M6 (HR 3.3, p = 0.03) were the independent high risk subzones.

  3. Prostate zones and cancer: lost in transition? - Nature

    www.nature.com/articles/s41585-021-00524-7

    The human prostate is divided into three zones based on its histological features: the peripheral zone (PZ), the transition zone (TZ) and the central zone (CZ). Each zone has variable...

  4. Prostate Zone Anatomy, Prostate Cancer and Imaging

    sperlingprostatecenter.com/prostate-zone-anatomy-prostate-cancer-and-imaging

    The largest area of the peripheral zone is at the back of the gland, closest to the rectal wall. When a doctor performs a digital rectal exam (DRE) it is the back surface of the gland he is feeling. This is important because about 70-80% of prostate cancers originate in the peripheral zone.

  5. Prostate cancer | Nature Reviews Disease Primers

    www.nature.com/articles/s41572-020-00243-0

    Millions of men are affected by prostate cancer each year. In high-income regions, the disease is among the most common solid malignancies and prognosis varies widely with age, ethnicity,...

  6. Prostate cancer - Wikipedia

    en.wikipedia.org/wiki/Prostate_cancer

    Signs and symptoms. Early prostate cancer usually causes no symptoms. As the cancer advances, it may cause erectile dysfunction, blood in the urine or semen, or trouble urinating – commonly including frequent urination and slow or weak urine stream. [4] .

  7. The Role of Prostate Zones in Cancer Progression

    www.clinicaloncologyonline.net/article/S0936-6555(22)00558-1/fulltext

    Purpose: The prostate is composed of four main areas: anterior fibrous septal area, transition zone (TZ), peripheral zone (PZ) and central zone (CZ), with more than 95% of tumours located in PZ and TZ [1,2].

  8. The peripheral zone extends posterolaterally around the gland from the apex to the base and represents the most common site in the prostate for developing prostate carcinomas. The central zone surrounds the ejaculatory duct apparatus and makes up the majority of the prostatic base.

  9. Zones of the Prostate - SEER Training

    www.training.seer.cancer.gov/prostate/anatomy/zones.html

    Scientists divide the prostate up into different zones according to their function. The zones are Central (CZ), Peripheral (PZ) and Transitional (TZ). Prostate cancer can begin and spread from any of these zones.

  10. The human prostate is divided into three zones based on its histological features: the peripheral zone (PZ), the transition zone (TZ) and the central zone (CZ). Each zone has variable prostate cancer incidence, prognosis and outcomes, with TZ prostate tumours having better clinical outcomes than PZ and CZ tumours.

  11. Prostate cancer represents the second most common cancer in men worldwide and the fifth most common cause of cancer death in men; in the United States, it is the most common...