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  2. Is Sildenafil Safe for This Common Male Problem? - AOL

    www.aol.com/sildenafil-safe-common-male-problem...

    After further trials, sildenafil citrate was approved by the Food and Drug Administration (FDA) in 1998 as the active ingredient in brand name Viagra, now a very well-known drug for ED. For most ...

  3. Viagra: What It Treats & Its Side Effects ( Plus What It Was ...

    www.aol.com/viagra-treats-side-effects-plus...

    Since 1998, the Pfizer-created drug sildenafil citrate has been a reliable treatment for the management of ED. But the active ingredient began its clinical journey as a medication intended to ...

  4. Sildenafil - Wikipedia

    en.wikipedia.org/wiki/Sildenafil

    Sildenafil 100 milligram tablets (prescription in the European Union) In June 2013 Pfizer's patent on sildenafil citrate expired in some member countries of the European Union, including Austria, Denmark, France, Germany, Ireland, Italy, The Netherlands, Spain, Sweden, the United Kingdom, and Switzerland.

  5. How to Take Viagra for Best Results - AOL

    www.aol.com/viagra-best-results-105700318.html

    Below, we’ve covered how you can take Viagra or generic sildenafil for optimal results, from the best time to take Viagra before intercourse to drug interactions and adverse effects that you ...

  6. Your ED Pill Guide: Everything You Need to Know Before ... - AOL

    www.aol.com/ed-pill-guide-everything-know...

    Viagra (or sildenafil) lasts three to five hours after it’s consumed. Cialis (tadalafil) has a half-life of 17.5 hours, meaning this drug lasts up to 36 hours after it’s consumed.

  7. PDE5 inhibitor - Wikipedia

    en.wikipedia.org/wiki/PDE5_inhibitor

    Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.

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