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Argininemia is an autosomal recessive urea cycle disorder where a deficiency of the enzyme arginase causes a buildup of arginine and ammonia in the blood.Ammonia, which is formed when proteins are broken down in the body, is toxic if levels become too high; the nervous system is especially sensitive to the effects of excess ammonia.
Arginine is the amino acid with the formula (H 2 N)(HN)CN(H)(CH 2) 3 CH(NH 2)CO 2 H. The molecule features a guanidino group appended to a standard amino acid framework. At physiological pH, the carboxylic acid is deprotonated (−CO 2 −) and both the amino and guanidino groups are protonated, resulting in a cation.
That being said, most nitric oxide supplements contain a blend of L-arginine and L-citrulline. Found naturally in the body and in certain foods, L-arginine and L-citrulline are amino acids , i.e ...
Argininosuccinic aciduria is an inherited disorder that causes the accumulation of argininosuccinic acid (also known as "ASA") in the blood and urine. Some patients may also have an elevation of ammonia, a toxic chemical, which can affect the nervous system.
L-arginine supplementation (or even nitric oxide supplements like nitrates) is typically not the most efficient way to produce nitric oxide, which is why people may use L-citrulline supplements to ...
Arginine/lysine, sold under the brand name Lysakare, is a fixed-dose combination medication used to protect the kidneys from radiation damage during cancer treatment with a radioactive medicine called lutetium (177 Lu) oxodotreotide. [2] It contains L-arginine hydrochloride and L-lysine hydrochloride. [2]
Arginine alpha-ketoglutarate (AAKG) is a salt of the amino acid arginine and alpha-ketoglutaric acid. It is marketed as a bodybuilding supplement. [1] Peer-reviewed studies have found no increase in muscle protein synthesis or improvement in muscle strength from use of AAKG as a dietary supplement. [1] [2] [3]
Nitroarginine, or N ω-nitro-l-arginine, also known as L-NOARG, is a nitro derivative of the amino acid arginine. [1] It is an inhibitor of nitric oxide synthase and hence a vasoconstrictor . As such, it finds widespread use as a biochemical tool in the study of nitric oxide and its biological effects.