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Insulin resistance, or low insulin sensitivity, happens when cells throughout the body don’t respond properly to the hormone insulin, especially cells in muscles, fat and the liver.
GLP-1 analogs resulted in weight loss and had more gastrointestinal side-effects, while in general dipeptidyl peptidase-4 (DPP-4) inhibitors were weight-neutral and are associated with increased risk for infection and headache. Both classes appear to present an alternative to other antidiabetic drugs.
Weight loss can help reduce the risk of further complications, other health related problems, and helps improve the effects of insulin on the body. [29] [30] Weight loss helps reduce the destruction of the beta cells, which produce insulin in the body, as well. [29] It is recommended for patients who have been diagnosed with T2D who are ...
GLP-1 drugs used for weight loss involve all kinds of side effects—good and not-so-good—that may or may not strike the average user. ... and bile duct problems, ... disease than people with ...
Common side effects include low blood sugar, nausea, dizziness, abdominal pain, and pain at the site of injection. [6] [10] Gastrointestinal side-effects tend to be strongest at the beginning of treatment period and subside over time. [10] Other serious side effects may include angioedema, pancreatitis, gallbladder disease, and kidney problems. [6]
Osmotic diarrhea, distension of the small bowel leading to crampy abdominal pain, and reduced blood volume can result. Late dumping syndrome occurs 2 to 3 hours after a meal. It results from excessive movement of sugar into the intestine, which raises the body's blood glucose level and causes the pancreas to increase its release of the hormone ...
Early initiation of insulin therapy for the long-term management of conditions such as type 2 diabetes would suggest that the use of insulin has unique benefits, however, with insulin therapy, there is a need to gradually raise the dose and the complexity of the regimen, as well as the likelihood of developing severe hypoglycemia which is why ...
Hyperinsulinism can be associated with several types of medical problems, which can be roughly divided into two broad and largely non-overlapping categories: those tending toward reduced sensitivity to insulin and high blood glucose levels (hyperglycemia), and those tending toward excessive insulin secretion and low glucose levels (hypoglycemia).