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Intermittent explosive disorder (IED), or episodic dyscontrol syndrome (EDS), is a mental and behavioral disorder characterized by explosive outbursts of anger or violence, often to the point of rage, that are disproportionate to the situation at hand (e.g., impulsive shouting, screaming, or excessive reprimanding triggered by relatively inconsequential events).
This is a list of investigational aggression drugs, or drugs that are currently under development for clinical use in the treatment of aggression but are not yet approved. Drugs used to treat aggression may also be known as "serenics". [1]
Intermittent explosive disorder or IED is a clinical condition of experiencing recurrent aggressive episodes that are out of proportion of any given stressor. Earlier studies reported a prevalence rate between 1–2% in a clinical setting, however a study done by Coccaro and colleagues in 2004 had reported about 11.1% lifetime prevalence and 3. ...
SRX246, also known as API-246, is a small-molecule, centrally-active, highly-selective vasopressin V 1A receptor antagonist which is under investigation by Azevan Pharmaceuticals for the treatment of affective and anger disorders. [1] [2] [3] It is an azetidinone derivative, and was developed from LY-307174 as a lead compound. [4]
Similarly, research on patterns of emotional (also called affective) experience [7] helped to identify dimensions of depression and anxiety symptoms. [8] Factor analytic studies of child symptomatology found clusters of emotional and behavioral problems that remain in use in research and clinical assessment today. [9]
Intermittent explosive disorder, pyromania, and kleptomania moved to this chapter from the DSM-IV chapter "Impulse-Control Disorders Not Otherwise Specified". [ 11 ] Antisocial personality disorder is listed here and in the chapter on personality disorders (but ADHD is listed under neurodevelopmental disorders).
Ross W. Greene is an American clinical child psychologist. The author of several books on child behavior—including The Explosive Child, Lost at School, Lost & Found, and Raising Human Beings—Greene originated the evidence-based Collaborative & Proactive Solutions (CPS) model of intervention.
Notably, intermittent explosive disorder is not associated with a higher likelihood of diagnosis with any of the other ICDs but is highly comorbid with disruptive behavior disorders in childhood. [84] Intermittent explosive disorder is likely to be re-classified in the DSM-V under the heading of disruptive, impulse control, and conduct ...