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Benzatropine , [2] known as benztropine in the United States and Japan, [3] is a medication used to treat movement disorders like parkinsonism and dystonia, as well as extrapyramidal side effects of antipsychotics, including akathisia. [4] It is not useful for tardive dyskinesia. [4] It is taken by mouth or by injection into a vein or muscle. [4]
The exact mechanism of action in parkinsonian syndromes is not precisely understood, but it is known that trihexyphenidyl blocks efferent impulses in parasympathetically innervated structures like smooth muscles (spasmolytic activity), salivary glands, and eyes . In higher doses direct central inhibition of cerebral motor centers may contribute.
Brain death is observed first. Breathing generally stops within seconds. However, euthanasia may be delayed in dogs that have deficient cardiac and circulatory function. [2] The pentobarbital component produces anaesthesia and rapid unconsciousness. A lethal dose causes loss of medullary respiration and vasomotor function.
Side effects in dogs and cats include hypersalivation, diarrhea, loss of appetite, and vomiting. [12] [16] Eight percent of dogs taking maropitant at doses meant to prevent motion sickness vomited right after, likely due to the local effects maropitant had on the gastrointestinal tract. Small amounts of food beforehand can prevent such post ...
Alpha-2 blockers (or α 2 blockers) are a subset of the alpha blocker class of drugs and are antagonists to the α 2 adrenergic receptor.They are mainly used in research, having found limited clinical application in human medicine.
Pimobendan is indicated for the management of the signs of mild, moderate, or severe congestive heart failure in dogs due to clinical myxomatous mitral valve disease (MMVD) or dilated cardiomyopathy (DCM); [1] [7] and for use with concurrent therapy for congestive heart failure (e.g.,furosemide, etc.) as appropriate on a case-by-case basis. [1]
Simply switching the patient from 40 mg of morphine to 10 mg of levorphanol would be dangerous due to dose accumulation, and hence frequency of administration should also be taken into account. There are other concerns about equianalgesic charts. Many charts derive their data from studies conducted on opioid-naive patients.
A 10-fold higher dosage of 10 mg/kg is needed to decrease serotonin levels as much as the reduction in dopamine levels at 1 mg/kg. [20] The low-effort bias of systemic administration of tetrabenazine also occurs when it is injected directly into the nucleus accumbens but not the overlying medial neostriatum (i.e., dorsal striatum ). [ 20 ]