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The rapid plasma reagin test (RPR test or RPR titer) is a type of rapid diagnostic test that looks for non-specific antibodies in the blood of the patient that may indicate an infection by syphilis or related non-venereal treponematoses. It is one of several nontreponemal tests for syphilis (along with the Wassermann test and the VDRL test).
Fig. 1: Microwells showing positive and negative TPHA test. The Treponema pallidum particle agglutination assay (also called TPPA test) is an indirect agglutination assay used for detection and titration of antibodies against the causative agent of syphilis, Treponema pallidum subspecies pallidum. It also detects other treponematoses. [citation ...
With nontreponemal tests, false-positive reactions can occur for a large number of reasons, the most common of which is other infections, both viral and bacterial. Additionally these tests may show false-negative when the patient's antibody titer is very high due to a hook effect (also called a prozone effect).
Latent syphilis has no symptoms and can last years. [2] In tertiary syphilis, there are gummas (soft, non-cancerous growths), neurological problems, or heart symptoms. [3] Syphilis has been known as "the great imitator", because it may cause symptoms similar to many other diseases. [2] [3] Syphilis is most commonly spread through sexual ...
In the most basic sense, there are four possible outcomes for a COVID-19 test, whether it’s molecular PCR or rapid antigen: true positive, true negative, false positive, and false negative.
It’s possible for an expired COVID test to show a false positive—but it’s also possible for a non-expired COVID test to show a false positive, Dr. Russo says. It’s just not super likely ...
Rouleaux causes red blood cells to stack together, which can mimic agglutination, causing a false positive result in the reverse grouping. This can be avoided by removing the plasma, replacing it with saline, and re-centrifuging the tube. Rouleaux will disappear once the plasma is replaced with saline, but true agglutination will persist.
A false positive Covid-19 test result can happen, but it’s rare, says Brian Labus, Ph.D., M.P.H., ... the virus that causes Covid-19, according to the CDC. The main types of tests include ...