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Weight loss drugs have been developed since the early twentieth century, and many have been banned or withdrawn from the market due to adverse effects, including deaths; other drugs proved ineffective. Although many earlier drugs were stimulants such as amphetamines, in the early 2020s, GLP-1 receptor agonists became popular for weight loss.
Intentional weight loss is the loss of total body mass as a result of efforts to improve fitness and health, or to change appearance through slimming. Weight loss is the main treatment for obesity, [1] [2] [3] and there is substantial evidence this can prevent progression from prediabetes to type 2 diabetes with a 7–10% weight loss and manage cardiometabolic health for diabetic people with a ...
[84] [85] Preoperative weight loss can reduce operative time and hospital stay. [84] [86] [87] although there is insufficient evidence whether preoperative weight loss may be beneficial to reduce long-term morbidity or complications. [87] [88] Weight loss and decreases in liver size may be independent from the amount of calorie restriction. [85]
Tirzepatide's efficacy for chronic weight management (weight reduction and maintenance) in combination with a reduced-calorie diet and increased physical activity was established in two randomized, double-blind, placebo-controlled trials of adults with obesity or overweight with at least one weight-related condition. [16]
The amount of weight loss achieved with orlistat varies. In one-year clinical trials, between 35.5% and 54.8% of subjects achieved a 5% or greater decrease in body mass, although not all of this mass was necessarily fat. Between 16.4% and 24.8% achieved at least a 10% decrease in body fat. [4]
After two years (120 weeks), the patients retained roughly one-third of their original weight loss (5.6% of the original 17.3% loss). [ 108 ] [ 109 ] In July 2023, the Icelandic Medicines Agency reported two cases of suicidal thoughts and one case of self-injury of users of the injection, prompting a safety assessment of Ozempic, [ 110 ] Wegovy ...
Weight management strategies most often focus on achieving healthy weights through slow but steady weight loss, followed by maintenance of an ideal body weight. [5] However, weight neutral approaches to health have also been shown to result in positive health outcomes.
The term bariatrics was coined around 1965, [2] from the Greek root bar- ("weight" as in barometer), suffix-iatr ("treatment," as in pediatrics), and suffix-ic ("pertaining to"). The field encompasses dieting, exercise and behavioral therapy approaches to weight loss, as well as pharmacotherapy and surgery. The term is also used in the medical ...
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