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Enalapril, sold under the brand name Vasotec among others, is an ACE inhibitor medication used to treat high blood pressure, diabetic kidney disease, and heart failure. [5] For heart failure, it is generally used with a diuretic, such as furosemide. [6] It is given by mouth or by injection into a vein. [5]
Enalaprilat is the active metabolite of enalapril. It is the first dicarboxylate-containing ACE inhibitor and was developed partly to overcome these limitations of captopril. The thiol functional group of captopril was replaced with a carboxylic acid group, but additional modifications were required to achieve a potency similar to captopril.
The ACE inhibitor enalapril has also been shown to reduce cardiac cachexia in patients with chronic heart failure. [53] Cachexia is a poor prognostic sign in patients with chronic heart failure. [54] ACE inhibitors are under early investigation for the treatment of frailty and muscle wasting (sarcopenia) in elderly patients without heart ...
“Both SGLT2 inhibitors and GLP-1 agonists are excellent drug categories that have improved the heart health of patients by improving many cardiovascular risk factors,” said Chen.
During the past decade, heart failure deaths have skyrocketed by 906% in people under age 45, and strokes among 18–44-year-olds are up nearly 15%.
Enalapril/hydrochlorothiazide, sold under the brand name Vaseretic among others, is a fixed-dose combination medication used for the treatment of hypertension (high blood pressure). [2] It contains enalapril , an angiotensin converting enzyme inhibitor , and hydrochlorothiazide a diuretic . [ 2 ]
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