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Mechanism of self-amplifying mRNA (saRNA) used for antigen production. The ORF encoding the antigen can also be substituted with a protein for use in protein replacement therapy. This sequence encodes the protein of interest, used as an antigen in the case of vaccines or for protein replacement therapies. The gene of interest replaces the viral ...
Therapeutic use of saRNAs have been suggested. They have been tested in animal models to treat bladder tumors, [8] liver carcinogenesis, [9] [10] pancreatic cancer, [11] and erectile dysfunction. [12] In 2016, a phase I clinical trial involving advanced liver cancer patients [13] was launched for the saRNA drug MTL-CEBPA. It aimed to complete ...
Kumpir (from Bulgarian компир, "potato"), a baked potato with various fillings, is a popular fast food in Turkey. [16] In its basic form, it is made with potatoes that are wrapped with foil and baked in special ovens. The potatoes are sliced down the middle and the insides are mixed with unsalted butter and puréed with kaşar cheese. [17]
Bring the water and the potatoes to a boil together. AP Photo/Matthew Mead. A common mistake when making mashed potatoes is adding the raw starch to already boiling water.. Instead, Halliburton ...
Fruitcake. Step one of a fruitcake is soaking pounds of dried fruit until it's plump and filled with bourbon. That takes up to 12 hours. Step two is simple: making and baking the loaves.
Place on a baking sheet or on a heatproof rack inserted inside a baking sheet. Bake potatoes until easily pierced with a fork and an instant-read thermometer inserted into the center registers 200 ...
Twice-baked potato: Prepared using baked potatoes, the interior of the potato is scooped out after being first-baked. Additional ingredients are added to the potato that is scooped out, and the mix is then placed in the potato shells and baked again. [16] Pictured is a twice baked potato with cheddar cheese, bacon and green onion topping. Zwieback
Idaho russet potatoes. Russet Burbank is a potato cultivar with dark brown skin and few eyes that is the most widely grown potato in North America. [1] A russet type, its flesh is white, dry, and mealy, and it is good for baking, mashing, and french fries (chips). [2] It is a common and popular potato. [3] [4]