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One alternative is to use a GnRH agonist instead of hCG. While this has been repeatedly shown to "virtually eliminate" OHSS risk, there is some controversy regarding the effect on pregnancy rates if a fresh non-donor embryo transfer is attempted, almost certainly due to a luteal phase defect.
Why does ovarian hyperstimulation syndrome occur? OHSS is a potential side effect of stimulating the ovaries to produce multiple eggs at the same time either during the first part of an IVF cycle ...
The addition of estrogen or hCG as adjunctives to progesterone do not appear to affect outcomes pregnancy rate and live birth rate in IVF. [1] In fact, luteal support with human chorionic gonadotropin (hCG) alone or as a supplement to progesterone has been associated with a higher risk of ovarian hyperstimulation syndrome (OHSS). [2]
Theca lutein cyst is a type of bilateral functional ovarian cyst filled with clear, straw-colored fluid. These cysts result from exaggerated physiological stimulation (hyperreactio luteinalis) due to elevated levels of beta-human chorionic gonadotropin (beta-hCG) or hypersensitivity to beta-hCG.
Severe cases often require hospitalization, removal of fluid from the abdomen, and replacement of fluid in the blood. OHSS is most prevalent in very high responders, almost always those with more than 20 developing ovarian follicles, who are triggered with hCG. One means of greatly reducing OHSS risk is to trigger with GnRH agonist instead of hCG.
Ozempic, Wegovy, Mounjaro, Zepbound lead to weight loss, which can help fertility in women with obesity. Doctors warn about birth control, pregnancy risks.
Geduldig v. Aiello, 417 U.S. 484 (1974), was an equal protection case in the United States in which the Supreme Court of the United States ruled on whether unfavorable treatment to pregnant women could count as sex discrimination.
One study looking into how Wegovy affects pregnant women and their babies is due to be completed in 2027. Wegovy comes in a higher dose than Ozempic, but this should give us clues into how safe ...