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Gilbert syndrome (GS) is a syndrome in which the liver of affected individuals processes bilirubin more slowly than the majority. [1] Many people never have symptoms. [ 1 ] Occasionally jaundice (a slight yellowish color of the skin or whites of the eyes) may occur.
Gilbert Syndrome, a hereditary disease affecting 5% of the US population, leads to stress-induced mild hyperbilirubinemia. [9] The mutated UGT1 gene produces defective UGT1A1 enzymes vital for bilirubin conjugation.
According to the Mayo Clinic, Gilbert syndrome is a common and harmless liver condition caused by a modified gene inherited from parents.
Gilbert syndrome can sometimes cause the skin or whites of the eyes to turn a yellowish color, per Mayo Clinic. It is a genetic disorder passed on from one or more parents. It is a genetic ...
Crigler-Najjar syndrome is much more severe and presents in newborns. Crigler-Najjar syndrome is the complete or near complete inactivity absence of UGT1A1 activity a more severe unconjugated hyperbilirubinemia compared to Gilbert Syndrome. [2] Dubin-Johnson syndrome and Rotor syndrome cause elevations in conjugated bilirubin. These conditions ...
According to the Mayo Clinic, Gilbert syndrome "is a common, harmless liver condition in which the liver doesn't properly process bilirubin." It is "an inherited genetic condition," and people who ...
Gilbert's syndrome and Crigler–Najjar syndrome have defects in the UDP-glucuronyl-transferase enzyme, affecting bilirubin conjugation. [6] The degree of rise in conjugated bilirubin is directly proportional to the degree of hepatocyte injury. Viral hepatitis can also cause the rise in conjugated bilirubin.
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