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Vitamin E affects gene expression [25] and is an enzyme activity regulator, such as for protein kinase C (PKC) – which plays a role in smooth muscle growth – with vitamin E participating in deactivation of PKC to inhibit smooth muscle growth.
For those looking to take a vitamin E supplement or ensure they are reaching the correct amount, Dr. Luke notes that the recommended daily amount of vitamin E is 15 mg/day of α-tocopherol.
Vitamin E was named "tocopherol" (from the Greek words tokos, meaning childbirth, and phero, meaning to bring forth) due to its presumed role in aiding conception. Subsequent research identified eight molecules in the vitamin E family, divided into tocopherols and tocotrienols: alpha, beta, delta, and gamma forms. [ 18 ]
A rare genetic defect of the TTPA gene results in people exhibiting a progressive neurodegenerative disorder known as ataxia with vitamin E deficiency (AVED) despite consuming normal amounts of vitamin E. Large amounts of alpha-tocopherol as a dietary supplement are needed to compensate for the lack of α-TTP repetitive, cut
This study provides new insight in vitamin E supplementation and suggests further research is needed with different forms of vitamin E as possible treatment options to abetalipoproteinemia. [ 26 ] Currently, there is a clinical study recruiting abetalipoproteinemia patients to study inherited retinal degenerative disease. [ 27 ]
Vitamin E deficiency in humans is a very rare condition, occurring as a consequence of abnormalities in dietary fat absorption or metabolism rather than from a diet low in vitamin E. [1] Collectively the EARs, RDAs, AIs and ULs for vitamin E and other essential nutrients are referred to as Dietary Reference Intakes (DRIs). [1]
Familial isolated vitamin e deficiency; Other names: Ataxia With Vitamin E Deficiency: Familial isolated vitamin E deficiency has an autosomal recessive pattern of inheritance. Specialty: Neurology Treatment: high-dose oral vitamin E supplementation
Reviews, however, have found that use of vitamin A (as β-carotene) and vitamin E supplements possibly can increase mortality. [ 118 ] [ 119 ] Other reviews have found no relationship between vitamin E and other vitamins with mortality. [ 120 ]
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